Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine

All currently approved antiviral drugs for the treatment of chronic hepatitis B virus (HBV) infection are nucleos(t)ide reverse transcriptase inhibitors (NRTI), which inhibit the DNA synthesis activity of the HBV polymerase. The polymerase is a unique reverse transcriptase (RT) that has a novel prot...

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Hlavní autoři: Jones, Scott A., Murakami, Eisuke, Delaney, William, Furman, Phillip, Hu, Jianming
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754288/
https://ncbi.nlm.nih.gov/pubmed/23774432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00599-13
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