In Vitro Mitochondrial Toxicity of Metacavir, a New Nucleoside Reverse Transcriptase Inhibitor for Treatment of Hepatitis B Virus

Therapy with nucleoside reverse transcriptase inhibitors (NRTIs) can be associated with mitochondrial toxicity. In vitro studies have been used to predict the predisposition for and characterize the mechanisms causing mitochondrial toxicity. Metacavir (PNA) is a novel synthetic nucleoside analog for...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhang, Pinghu, Zhang, Luyong, Jiang, Zhenzhou, Wang, Tao, Chen, Hongkui, Xiong, Yating, Li, Zhan
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976109/
https://ncbi.nlm.nih.gov/pubmed/20805401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00794-10
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