In Vitro Mitochondrial Toxicity of Metacavir, a New Nucleoside Reverse Transcriptase Inhibitor for Treatment of Hepatitis B Virus

Therapy with nucleoside reverse transcriptase inhibitors (NRTIs) can be associated with mitochondrial toxicity. In vitro studies have been used to predict the predisposition for and characterize the mechanisms causing mitochondrial toxicity. Metacavir (PNA) is a novel synthetic nucleoside analog for...

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Detalhes bibliográficos
Main Authors: Zhang, Pinghu, Zhang, Luyong, Jiang, Zhenzhou, Wang, Tao, Chen, Hongkui, Xiong, Yating, Li, Zhan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976109/
https://ncbi.nlm.nih.gov/pubmed/20805401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00794-10
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