In Vitro Mitochondrial Toxicity of Metacavir, a New Nucleoside Reverse Transcriptase Inhibitor for Treatment of Hepatitis B Virus

Therapy with nucleoside reverse transcriptase inhibitors (NRTIs) can be associated with mitochondrial toxicity. In vitro studies have been used to predict the predisposition for and characterize the mechanisms causing mitochondrial toxicity. Metacavir (PNA) is a novel synthetic nucleoside analog for...

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Hlavní autoři: Zhang, Pinghu, Zhang, Luyong, Jiang, Zhenzhou, Wang, Tao, Chen, Hongkui, Xiong, Yating, Li, Zhan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976109/
https://ncbi.nlm.nih.gov/pubmed/20805401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00794-10
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