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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
The replication of the hepatitis C viral (HCV) genome is accomplished by the NS5B RNA-dependent RNA polymerase (RdRp), for which mechanistic understanding and structure-guided drug design efforts have been hampered by its propensity to crystallize in a closed, polymerization-incompetent state. The r...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3393583/ https://ncbi.nlm.nih.gov/pubmed/22496223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00386-12 |
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