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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
The replication of the hepatitis C viral (HCV) genome is accomplished by the NS5B RNA-dependent RNA polymerase (RdRp), for which mechanistic understanding and structure-guided drug design efforts have been hampered by its propensity to crystallize in a closed, polymerization-incompetent state. The r...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3393583/ https://ncbi.nlm.nih.gov/pubmed/22496223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00386-12 |
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