Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

The replication of the hepatitis C viral (HCV) genome is accomplished by the NS5B RNA-dependent RNA polymerase (RdRp), for which mechanistic understanding and structure-guided drug design efforts have been hampered by its propensity to crystallize in a closed, polymerization-incompetent state. The r...

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Detaylı Bibliyografya
Asıl Yazarlar: Mosley, Ralph T., Edwards, Thomas E., Murakami, Eisuke, Lam, Angela M., Grice, Rena L., Du, Jinfa, Sofia, Michael J., Furman, Philip A., Otto, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2012
Konular:
Structure and Assembly
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393583/
https://ncbi.nlm.nih.gov/pubmed/22496223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00386-12
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