Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

Resistance to the 2′-F-2′-C-methylguanosine monophosphate nucleotide hepatitis C virus (HCV) inhibitors PSI-352938 and PSI-353661 was associated with a combination of amino acid changes (changes of S to G at position 15 [S15G], C223H, and V321I) within the genotype 2a nonstructural protein 5B (NS5B)...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lam, Angela M., Edwards, Thomas E., Mosley, Ralph T., Murakami, Eisuke, Bansal, Shalini, Lugo, Christopher, Bao, Haiying, Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249362/
https://ncbi.nlm.nih.gov/pubmed/25182647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03847-14
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