Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) is a potent specific inhibitor of hepatitis C virus (HCV) RNA synthesis in Huh-7 replicon cells. To inhibit the HCV NS5B RNA polymerase, PSI-6130 must be phosphorylated to the 5′-triphosphate form. The phosphorylation of PSI-6130 and inhibition o...

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Main Authors: Murakami, Eisuke, Bao, Haiying, Ramesh, Mangala, McBrayer, Tamara R., Whitaker, Tony, Micolochick Steuer, Holly M., Schinazi, Raymond F., Stuyver, Lieven J., Obikhod, Aleksandr, Otto, Michael J., Furman, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797721/
https://ncbi.nlm.nih.gov/pubmed/17101674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00400-06
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