Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2′-Deoxy-2′-Fluorocytidine

2′-Deoxy-2′-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5′-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These...

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Bibliographische Detailangaben
Hauptverfasser: Stuyver, Lieven J., McBrayer, Tamara R., Whitaker, Tony, Tharnish, Phillip M., Ramesh, Mangala, Lostia, Stefania, Cartee, Leanne, Shi, Junxing, Hobbs, Ann, Schinazi, Raymond F., Watanabe, Kyoichi A., Otto, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC321524/
https://ncbi.nlm.nih.gov/pubmed/14742230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.2.651-654.2004
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