Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

Treatment with antimetabolites results in chemically induced low nucleoside triphosphate pools and cell cycle arrest in exponentially growing cells. Since steady-state levels of hepatitis C virus (HCV) replicon RNA were shown to be dependent on exponential growth of Huh-7 cells, the effects of antim...

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Main Authors: Stuyver, Lieven J., McBrayer, Tamara R., Tharnish, Phillip M., Hassan, Abdalla E. A., Chu, Chung K., Pankiewicz, Krzysztof W., Watanabe, Kyochi A., Schinazi, Raymond F., Otto, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC228517/
https://ncbi.nlm.nih.gov/pubmed/12970456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.19.10689-10694.2003
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