Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates

Thirty novel α- and β-D-2′-deoxy-2′-fluoro-2′-C-methyl-7-deazapurine nucleoside analogs were synthesized and evaluated for in vitro antiviral activity. Several α- and β-7-deazapurine nucleoside analogs exhibited modest anti-HCV activity and cytotoxicity. Four synthesized 7-deazapurine nucleoside pho...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shi, Junxing, Zhou, Longhu, Zhang, Hongwang, McBrayer, Tamara R., Detorio, Mervi A., Johns, Melissa, Bassit, Leda, Powdrill, Megan H., Whitaker, Tony, Coats, Steven J., Götte, Matthias, Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242417/
https://ncbi.nlm.nih.gov/pubmed/22014549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.089
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados