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Synthesis and anti-HCV activity of a series of β-D-2′-deoxy-2′-dibromo nucleosides and their corresponding phosphoramidate prodrugs
Several β-D-2′-deoxy-2′-substituted nucleoside analogs have displayed potent and selective anti-HCV activities and some of them have reached human clinical trials. In that regard, we report herein the synthesis of a series of 2′-deoxy, 2′-dibromo substituted U, C, G and A nucleosides 10a–d and their...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693771/ https://ncbi.nlm.nih.gov/pubmed/29066308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.10.024 |
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