Wird geladen...

Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl Nucleosides

[Image: see text] A new and facile synthetic pathway to metabolically stable 5′-methylene-bis(pivaloyloxymethyl)(POM)phosphonate furanonucleoside prodrugs is reported. The key step involves a Horner-Wadsworth-Emmons reaction of a tetra(pivaloyloxymethyl) bisphosphonate salt with appropriately protec...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Pradere, Ugo, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470451/
https://ncbi.nlm.nih.gov/pubmed/22917194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol301937v
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!