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Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl Nucleosides

[Image: see text] A new and facile synthetic pathway to metabolically stable 5′-methylene-bis(pivaloyloxymethyl)(POM)phosphonate furanonucleoside prodrugs is reported. The key step involves a Horner-Wadsworth-Emmons reaction of a tetra(pivaloyloxymethyl) bisphosphonate salt with appropriately protec...

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Hlavní autoři: Pradere, Ugo, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470451/
https://ncbi.nlm.nih.gov/pubmed/22917194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol301937v
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