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Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection
An efficient method for the synthesis of nucleoside phosphoramidates prodrugs (6a–f) has been developed that employs a simple protection/deprotection sequence of the nucleoside with benzyloxycarbonyl (Cbz). The coupling reaction of Cbz-protected derivatives (5a–f) with phenyl-(ethoxy-L-alaninyl)-pho...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444294/ https://ncbi.nlm.nih.gov/pubmed/22993455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.05.046 |
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