Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs

The synthesis of 9-(β-D-1,3-dioxolan-4-yl)2,6-diaminopurine nucleoside phosphoramidate prodrugs as well as various 2-amino-6-carbamoylpurine dioxolane derivatives and their phosphoramidates prodrugs is reported. Their ability to block HIV and HBV replication along with their cytotoxicity toward HepG...

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Publicado en:Bioorg Med Chem
Main Authors: Cho, Jong Hyun, Bondana, Lavanya, Detorio, Mervi A., Montero, Cathy, Bassit, Leda C., Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312240/
https://ncbi.nlm.nih.gov/pubmed/25458500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.10.003
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