Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates

A novel series of tetrafluoro and hexafluoro acyclic nucleosides and their phosphoramidates were successfully prepared from commercially available 2,2,3,3-tetrafluoro-1,4-butanediol and 2,2,3,3,4,4-hexafluoro-1,5-pentanediol in four to six steps. Their ability to block HIV, HCV, HSV-1, and HBV repli...

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Détails bibliographiques
Publié dans:Nucleosides Nucleotides Nucleic Acids
Auteurs principaux: Mahmoud, Sawsan, Li, Hao, McBrayer, Tamara R., Bassit, Leda, Hammad, Sherif F., Coats, Steven J., Amblard, Franck, Schinazi, Raymond F.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714494/
https://ncbi.nlm.nih.gov/pubmed/27759481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770.2016.1218023
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