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Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs

Herein, we report the synthesis of novel 2′,2′,3′,3′-tetrafluorinated nucleoside analogs along with their phosphoramidate prodrugs. A tetrafluoro ribose moiety was coupled with different Boc/benzoyl-protected nucleobases under Mitsunobu conditions. After deprotection, tetrafluorinated nucleosides 13...

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Detalhes bibliográficos
Publicado no:Tetrahedron Lett
Main Authors: Sari, Ozkan, Bassit, Leda, Gavegnano, Christina, McBrayer, Tamara R., McCormick, Louise, Cox, Bryan, Coats, Steven J., Amblard, Franck, Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289701/
https://ncbi.nlm.nih.gov/pubmed/28163339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2017.01.006
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