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Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs
Herein, we report the synthesis of novel 2′,2′,3′,3′-tetrafluorinated nucleoside analogs along with their phosphoramidate prodrugs. A tetrafluoro ribose moiety was coupled with different Boc/benzoyl-protected nucleobases under Mitsunobu conditions. After deprotection, tetrafluorinated nucleosides 13...
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| Опубликовано в: : | Tetrahedron Lett |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5289701/ https://ncbi.nlm.nih.gov/pubmed/28163339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2017.01.006 |
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