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Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs
Herein, we report the synthesis of novel 2′,2′,3′,3′-tetrafluorinated nucleoside analogs along with their phosphoramidate prodrugs. A tetrafluoro ribose moiety was coupled with different Boc/benzoyl-protected nucleobases under Mitsunobu conditions. After deprotection, tetrafluorinated nucleosides 13...
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| Publicado en: | Tetrahedron Lett |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5289701/ https://ncbi.nlm.nih.gov/pubmed/28163339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2017.01.006 |
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