Synthesis and antiviral evaluation of 2′,3′-dideoxy-2′,3′-difluoro-D-arabinofuranosyl 2,6-disubstituted purine nucleosides

The synthesis of new 2,6-disubstituted purine 2′,3′-dideoxy-2′,3′-difluoro-D-arabino nucleosides is reported. Their ability to block HIV and HCV replication along with their cytotoxicity toward Huh-7 cells, human lymphocyte, CEM and Vero cells was also assessed. Among them, β-2,6-diaminopurine nucle...

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Publicado en:Heterocycl Comm
Main Authors: Schinazi, Raymond F., Sivets, Grigorii G., Detorio, Mervi A., McBrayer, Tami R., Whitaker, Tony, Coats, Steven J., Amblard, Franck
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313041/
https://ncbi.nlm.nih.gov/pubmed/34316093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/hc-2015-0174
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