Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

[Image: see text] A series of 3,9-dihydro-9-oxo-5H-imidazo[1,2-A]purine nucleosides (tricylic nucleosides) were synthesized from 9-[4-α-(hydroxymethyl)cyclopent-2-ene-1-α-yl]guanine (CBV) 5, (−)-β-D-(2R,4R)-1,3-dioxolane-guanosine (DXG) 6, 3’-azido-3’-deoxy-guanosine (AZG) 7, and 2’-C-methylguanosin...

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Detalhes bibliográficos
Main Authors: Amblard, Franck, Fromentin, Emilie, Detorio, Mervi, Obikhod, Alexander, Rapp, Kimberly L., McBrayer, Tamara R., Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423956/
https://ncbi.nlm.nih.gov/pubmed/19433343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2009.04.003
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