Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

The synthesis of new ribo and 2’-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells

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Dettagli Bibliografici
Autori principali: Zhou, Longhu, Amblard, Franck, Zhang, Hongwang, McBrayer, Tamara R., Detorio, Mervi A., Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704321/
https://ncbi.nlm.nih.gov/pubmed/23623492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.03.077
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