Synthesis and evaluation of novel potent HCV NS5A inhibitors

Judicious modifications to the structure of the previously reported HCV NS5A inhibitor1, resulted in more potent anti-HCV compounds with similar and in some cases improved toxicity profiles. The synthesis of nineteen new NS5A inhibitors is reported along with their ability to block HCV replication i...

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Hongwang, Zhou, Longhu, Amblard, Franck, Shi, Junxing, Bobeck, Drew R., Tao, Sijia, McBrayer, Tamara R., Tharnish, Phillip M., Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389222/
https://ncbi.nlm.nih.gov/pubmed/22704887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.039
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