Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors

NS5A inhibitors are a new class of direct-acting antiviral agents which display very potent anti-HCV activity in vitro and in humans. Rationally designed modifications to the central biphenyl linkage of a known NS5A series led to selection of several compounds that were synthesized and evaluated in...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Shi, Junxing, Zhou, Longhu, Amblard, Franck, Bobeck, Drew R., Zhang, Hongwang, Liu, Peng, Bondada, Lavanya, McBrayer, Tamara R., Tharnish, Phillip M., Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732024/
https://ncbi.nlm.nih.gov/pubmed/22507961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.03.089
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