Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors

Herein, we report the synthesis and structure–activity relationship studies of new analogs of boceprevir 1 and telaprevir 2. Introduction of azetidine and spiroazetidines as a P2 substituent that replaced the pyrrolidine moiety of 1 and 2 led to the discovery of a potent hepatitis C protease inhibit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bondada, Lavanya, Rondla, Ramu, Pradere, Ugo, Liu, Peng, Li, Chengwei, Bobeck, Drew, McBrayer, Tamara, Tharnish, Philip, Courcambeck, Jerome, Halfon, Philippe, Whitaker, Tony, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042666/
https://ncbi.nlm.nih.gov/pubmed/24135727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.09.068
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