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Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors
Herein, we report the synthesis and structure–activity relationship studies of new analogs of boceprevir 1 and telaprevir 2. Introduction of azetidine and spiroazetidines as a P2 substituent that replaced the pyrrolidine moiety of 1 and 2 led to the discovery of a potent hepatitis C protease inhibit...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2013
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042666/ https://ncbi.nlm.nih.gov/pubmed/24135727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.09.068 |
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