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Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors
The design and synthesis of new non-symmetrical NS5A inhibitors with sulfur containing amino acids is reported along with their ability to block HCV replication in an HCV 1b replicon system. These compounds display EC(50) values in the picomolar range with a large therapeutic index (>10(6)). More...
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| Foilsithe in: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2015
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538959/ https://ncbi.nlm.nih.gov/pubmed/26099532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.031 |
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