Synthesis and evaluation of non-dimeric HCV NS5A inhibitors

Based on the symmetrical bidentate structure of the NS5A inhibitor BMS-790052, a series of new monodentate molecules were designed. The synthesis of 36 new non-dimeric NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system. Among them compound 5a s...

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Hoofdauteurs: Amblard, Franck, Zhang, Hongwang, Zhou, Longhu, Shi, Junxing, Bobeck, Drew R., Nettles, James H., Chavre, Satish, McBrayer, Tamara R., Tharnish, Philip, Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602317/
https://ncbi.nlm.nih.gov/pubmed/23466233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.02.023
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