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Synthesis and anti-HCV activity of a series of β-D-2′-deoxy-2′-dibromo nucleosides and their corresponding phosphoramidate prodrugs

Several β-D-2′-deoxy-2′-substituted nucleoside analogs have displayed potent and selective anti-HCV activities and some of them have reached human clinical trials. In that regard, we report herein the synthesis of a series of 2′-deoxy, 2′-dibromo substituted U, C, G and A nucleosides 10a–d and their...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Chen, Zhe, Cox, Bryan D., Garnier-Amblard, Ethel C., McBrayer, Tamara R., Coats, Steven J., Schinazi, Raymond F., Amblard, Franck
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693771/
https://ncbi.nlm.nih.gov/pubmed/29066308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.10.024
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