β-d-2′-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms

The conversion of selected β-d-2,6-diaminopurine nucleosides (DAPNs) to their phosphoramidate prodrug (PD) substantially blocks the conversion to the G-analog allowing for the generation of two bioactive nucleoside triphosphates (NTPs) in human hepatocytes. A variety of 2′-C-methyl DAPN-PDs were pre...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Zhou, Longhu, Zhang, Hong-wang, Tao, Sijia, Bassit, Leda, Whitaker, Tony, McBrayer, Tamara R., Ehteshami, Maryam, Amiralaei, Sheida, Pradere, Ugo, Cho, Jong Hyun, Amblard, Franck, Bobeck, Drew, Detorio, Mervi, Coats, Steven J., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714489/
https://ncbi.nlm.nih.gov/pubmed/25849312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501874e
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