Intracellular metabolism and potential cardiotoxicity of a β-D-2’-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication

β-D-2’-C-Methyl-2,6-diaminopurine ribonucleoside (2’-C-Me-DAPN) phosphoramidate prodrug (DAPN-PD) is a selective hepatitis C virus inhibitor that is metabolized intracellularly into two active metabolites: 2’-C-Methyl-DAPN triphosphate (2’-C-Me-DAPN-TP) and 2’-C-methyl-guanosine 5’-triphosphate (2’-...

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Detalhes bibliográficos
Publicado no:Nucleosides Nucleotides Nucleic Acids
Main Authors: Tao, Sijia, Zhou, Longhu, Zhang, Hongwang, Zhou, Shaoman, Amiralaei, Sheida, Shelton, Jadd, Ehteshami, Maryam, Jiang, Yong, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717620/
https://ncbi.nlm.nih.gov/pubmed/31595843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770.2019.1671594
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