Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

Antzeko izenburuak

• Intracellular metabolism and potential cardiotoxicity of a β-D-2’-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication
  nork: Tao, Sijia, et al.
  Argitaratua: (2019)
• β-d-2′-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5′-Triphosphate Forms
  nork: Zhou, Longhu, et al.
  Argitaratua: (2015)
• Synthesis and Evaluation of 2,6-Modified Purine 2′-C-Methyl Ribonucleosides as Inhibitors of HCV Replication
  nork: Zhou, Longhu, et al.
  Argitaratua: (2015)
• Synthesis and anti-HCV activity of β-d-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs
  nork: Ovadia, Reuben, et al.
  Argitaratua: (2019)
• Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates
  nork: Mahmoud, Sawsan, et al.
  Argitaratua: (2016)