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Discovery of a Series of 2′-α-Fluoro,2′-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

Hepatitis C virus (HCV) nucleoside inhibitors display pan-genotypic activity, a high barrier to the selection of resistant virus, and are some of the most potent direct-acting agents with durable sustained virologic response in humans. Herein, we report, the discovery of β-d-2′-Br,2′-F-uridine phosp...

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Vydáno v:J Med Chem
Hlavní autoři: Mengshetti, Seema, Zhou, Longhu, Sari, Ozkan, De Schutter, Coralie, Zhang, Hongwang, Cho, Jong Hyun, Tao, Sijia, Bassit, Leda C., Verma, Kiran, Domaoal, Robert A., Ehteshami, Maryam, Jiang, Yong, Ovadia, Reuben, Kasthuri, Mahesh, Russell, Olivia Ollinger, McBrayer, Tamara, Whitaker, Tony, Pattassery, Judy, Pascual, Maria Luz, Uher, Lothar, Lin, Biing Y., Lee, Sam, Amblard, Franck, Coats, Steven J., Schinazi, Raymond F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722249/
https://ncbi.nlm.nih.gov/pubmed/30653317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01300
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