Bifunctional Inhibition of HIV-1 Reverse Transcriptase: A First Step in Designing a Bifunctional Triphosphate()

The onset of resistance to approved anti-AIDS drugs by HIV necessitates the search for novel inhibitors of HIV-1 reverse transcriptase (RT). Developing single molecular agents concurrently occupying the nucleoside and nonnucleoside binding sites in RT is an intriguing idea but the proof-of-concept h...

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Main Authors: Piao, Dongyuan, Basavapathruni, Aravind, Iyidogan, Pinar, Dai, Guangxiu, Hinz, Wolfgang, Ray, Adrian S., Murakami, Eisuke, Feng, Joy Y., You, Fei, Dutschman, Ginger E., Austin, David J., Parker, Kathlyn A., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580853/
https://ncbi.nlm.nih.gov/pubmed/23380374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.015
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https://ncbi.nlm.nih.gov/pmc/articles/PMC3580853/
https://ncbi.nlm.nih.gov/pubmed/23380374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.12.015