Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

Delivery of pharmacologically active nucleoside triphosphate analogs to sites of viral infection is challenging. In prior work we identified a 2′-C-methyl-1′-cyano-7-deaza-adenosine C-nucleotide analog with desirable selectivity and potency for the treatment of hepatitis C virus (HCV) infection. How...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Feng, Joy Y., Wang, Ting, Park, Yeojin, Babusis, Darius, Birkus, Gabriel, Xu, Yili, Voitenleitner, Christian, Fenaux, Martijn, Yang, Huiling, Eng, Stacey, Tirunagari, Neeraj, Kirschberg, Thorsten, Cho, Aesop, Ray, Adrian S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105845/
https://ncbi.nlm.nih.gov/pubmed/29866875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00620-18
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