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Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases α, δ, and ɛ*
Tenofovir diphosphate (PMPApp) is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ*, with values for the K(i) for PMPApp ((PMPApp)K(i)) relative to the K(m) for dATP ((dATP)K(m)) of 10.2, 10.2, and 15.2, respectively. Its incorporation into DNA was about 1,000-fold less efficient than that of d...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC127178/ https://ncbi.nlm.nih.gov/pubmed/11959615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1610-1613.2002 |
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