Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases α, δ, and ɛ*

Tenofovir diphosphate (PMPApp) is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ*, with values for the K(i) for PMPApp ((PMPApp)K(i)) relative to the K(m) for dATP ((dATP)K(m)) of 10.2, 10.2, and 15.2, respectively. Its incorporation into DNA was about 1,000-fold less efficient than that of d...

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Bibliografski detalji
Glavni autori: Birkuš, Gabriel, Hájek, Miroslav, Kramata, Pavel, Votruba, Ivan, Holý, Antonín, Otová, Berta
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Antiviral Agents
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC127178/
https://ncbi.nlm.nih.gov/pubmed/11959615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1610-1613.2002
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