Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

K65R is a primary reverse transcriptase (RT) mutation selected in human immunodeficiency virus type 1-infected patients taking antiretroviral regimens containing tenofovir disoproxil fumarate or other nucleoside analog RT drugs. We determined the crystal structures of K65R mutant RT cross-linked to...

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Bibliografiske detaljer
Main Authors: Das, Kalyan, Bandwar, Rajiv P., White, Kirsten L., Feng, Joy Y., Sarafianos, Stefan G., Tuske, Steven, Tu, Xiongying, Clark, Arthur D., Boyer, Paul L., Hou, Xiaorong, Gaffney, Barbara L., Jones, Roger A., Miller, Michael D., Hughes, Stephen H., Arnold, Eddy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787370/
https://ncbi.nlm.nih.gov/pubmed/19812032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022525
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