Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC)

بواسطة Liotta, Dennis C., Painter, George R.
الحاوية / القاعدة Acc Chem Res (2016)

Consortia’s critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective

بواسطة Everts, Maaike, Suto, Mark J, Painter, George R, Whitley, Richard J
الحاوية / القاعدة Future Virol (2016)

Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

بواسطة Painter, George R, Natchus, Michael G, Cohen, Oren, Holman, Wendy, Painter, Wendy P
الحاوية / القاعدة Curr Opin Virol (2021)

Quantitative Efficacy Paradigms of the Influenza Clinical Drug Candidate EIDD-2801 in the Ferret Model

بواسطة Toots, Mart, Yoon, Jeong-Joong, Hart, Michael, Natchus, Michael G, Painter, George R, Plemper, Richard K
الحاوية / القاعدة Transl Res (2019)

Efficacy of CMX001 Against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

بواسطة Quenelle, Debra C., Lampert, Bernhardt, Collins, Deborah J., Rice, Terri L., Painter, George R., Kern, Earl R.
منشور في 2010

Preclinical and clinical development of the anti-HIV, anti-HBV oxathiolane nucleoside analog emtricitabine

بواسطة Painter, George R., Rimsky, Laurence T., Furman, Phillip A., Liotta, Dennis C., Schinazi, Raymond F., Quinn, Joseph B.
الحاوية / القاعدة Frontiers in Viral Hepatitis (2003)

Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model

بواسطة Toth, Karoly, Spencer, Jacqueline F., Dhar, Debanjan, Sagartz, John E., Buller, R. Mark L., Painter, George R., Wold, William S. M.
منشور في 2008

Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

بواسطة Quenelle, Debra C., Prichard, Mark N., Keith, Kathy A., Hruby, Dennis E., Jordan, Robert, Painter, George R., Robertson, Alice, Kern, Earl R.
منشور في 2007

Analysis of Ribonucleotide 5′-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays

بواسطة Lu, Gaofei, Bluemling, Gregory R., Collop, Paul, Hager, Michael, Kuiper, Damien, Gurale, Bharat P., Painter, George R., De La Rosa, Abel, Kolykhalov, Alexander A.
الحاوية / القاعدة Antimicrob Agents Chemother (2017)

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2

بواسطة Painter, Wendy P., Holman, Wayne, Bush, Jim A., Almazedi, Firas, Malik, Hamzah, Eraut, Nicola C. J. E., Morin, Merribeth J., Szewczyk, Laura J., Painter, George R.
الحاوية / القاعدة Antimicrob Agents Chemother (2021)

Analysis of the Potential for N(4)-Hydroxycytidine To Inhibit Mitochondrial Replication and Function

بواسطة Sticher, Zachary M., Lu, Gaofei, Mitchell, Deborah G., Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R., Guthrie, David B., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A.
الحاوية / القاعدة Antimicrob Agents Chemother (2020)

Development of Hexadecyloxypropyl Tenofovir (CMX157) for Treatment of Infection Caused by Wild-Type and Nucleoside/Nucleotide-Resistant HIV

بواسطة Lanier, E. Randall, Ptak, Roger G., Lampert, Bernhard M., Keilholz, Laurie, Hartman, Tracy, Buckheit, Robert W., Mankowski, Marie K., Osterling, Mark C., Almond, Merrick R., Painter, George R.
منشور في 2010

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5′-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase

بواسطة Lu, Gaofei, Bluemling, Gregory R., Mao, Shuli, Hager, Michael, Gurale, Bharat P., Collop, Paul, Kuiper, Damien, Sana, Kasinath, Painter, George R., De La Rosa, Abel, Kolykhalov, Alexander A.
الحاوية / القاعدة Antimicrob Agents Chemother (2018)

Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infection...

بواسطة Painter, George R., Almond, Merrick R., Trost, Lawrence C., Lampert, Bernhard M., Neyts, Johan, De Clercq, Erik, Korba, Brent E., Aldern, Kathy A., Beadle, James R., Hostetler, Karl Y.
منشور في 2007

Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]-Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections

بواسطة Painter, George R., Almond, Merrick R., Trost, Lawrence C., Lampert, Bernhard M., Neyts, Johan, De Clercq, Erik, Korba, Brent E., Aldern, Kathy A., Beadle, James R., Hostetler, Karl Y.
منشور في 2007

β-d-N(4)-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

بواسطة Urakova, Nadya, Kuznetsova, Valeriya, Crossman, David K., Sokratian, Arpine, Guthrie, David B., Kolykhalov, Alexander A., Lockwood, Mark A., Natchus, Michael G., Crowley, Michael R., Painter, George R., Frolova, Elena I., Frolov, Ilya
الحاوية / القاعدة J Virol (2018)

Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

بواسطة Furman, Phillip A., Jeffrey, Jerry, Kiefer, Laura L., Feng, Joy Y., Anderson, Karen S., Borroto-Esoda, Katyna, Hill, Edgar, Copeland, William C., Chu, Chung K., Sommadossi, Jean-Pierre, Liberman, Irina, Schinazi, Raymond F., Painter, George R.
منشور في 2001

4’-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

بواسطة Sourimant, Julien, Lieber, Carolin M, Aggarwal, Megha, Cox, Robert M, Wolf, Josef D, Yoon, Jeong-Joong, Toots, Mart, Ye, Chengin, Sticher, Zachary, Kolykhalov, Alexander A, Martinez-Sobrido, Luis, Bluemling, Gregory R, Natchus, Michael G, Painter, George R, Plemper, Richard K
الحاوية / القاعدة bioRxiv (2021)

Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

بواسطة Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.
الحاوية / القاعدة J Virol (2019)

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

بواسطة Toots, Mart, Yoon, Jeong-Joong, Cox, Robert M, Hart, Michael, Sticher, Zachary M, Makhsous, Negar, Plesker, Roland, Barrena, Alec H, Reddy, Prabhakar G., Mitchell, Deborah G, Shean, Ryan C, Bluemling, Gregory R, Kolykhalov, Alexander A, Greninger, Alexander L, Natchus, Michael G, Painter, George R, Plemper, Richard K
الحاوية / القاعدة Sci Transl Med (2019)