Activity and Mechanism of Action of N-Methanocarbathymidine against Herpesvirus and Orthopoxvirus Infections

per Prichard, Mark N., Keith, Kathy A., Quenelle, Debra C., Kern, Earl R.
Publicat 2006

Evaluation of Nucleoside Phosphonates and Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication

per Keith, Kathy A., Hitchcock, Michael J. M., Lee, William A., Holý, Antonin, Kern, Earl R.
Publicat 2003

5-(Dimethoxymethyl)-2′-Deoxyuridine: A Novel Gem Diether Nucleoside with Anti-Orthopoxvirus Activity

per Fan, Xuesen, Zhang, Xinying, Zhou, Longhu, Keith, Kathy A., Kern, Earl R., Torrence, Paul F.
Publicat a J Med Chem (2006)

Inhibitory Activity of Alkoxyalkyl and Alkyl Esters of Cidofovir and Cyclic Cidofovir against Orthopoxvirus Replication In Vitro

per Keith, Kathy A., Wan, William B., Ciesla, Stephanie L., Beadle, James R., Hostetler, Karl Y., Kern, Earl R.
Publicat 2004

Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

per Prichard, Mark N, Kern, Earl R, Quenelle, Debra C, Keith, Kathy A, Moyer, Richard W, Turner, Peter C
Publicat 2008

Toward Orthopoxvirus Countermeasures: A Novel Heteromorphic Nucleoside of Unusual Structure

per Fan, Xuesen, Zhang, Xinying, Zhou, Longhu, Keith, Kathy A., Prichard, Mark N., Kern, Earl R., Torrence, Paul F.
Publicat a J Med Chem (2006)

Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice

per Quenelle, Debra C., Buller, R. M. L., Parker, Scott, Keith, Kathy A., Hruby, Dennis E., Jordan, Robert, Kern, Earl R.
Publicat 2007

Synthesis and Antiviral Evaluation of Alkoxyalkyl Phosphate Conjugates of Cidofovir and Adefovir

per Ruiz, Jacqueline C., Beadle, James R., Aldern, Kathy A., Keith, Kathy A., Hartline, Caroll B., Kern, Earl R., Hostetler, Karl Y.
Publicat 2006

Activities of Certain 5-Substituted 4′-Thiopyrimidine Nucleosides against Orthopoxvirus Infections

per Kern, Earl R., Prichard, Mark N., Quenelle, Debra C., Keith, Kathy A., Tiwari, Kamal N., Maddry, Joseph A., Secrist, John A.
Publicat 2009

Identification of Protein-Protein Interaction Inhibitors Targeting Vaccinia Virus Processivity Factor for Development of Antiviral Agents

per Schormann, Norbert, Sommers, Charnell Inglis, Prichard, Mark N., Keith, Kathy A., Noah, James W., Nuth, Manunya, Ricciardi, Robert P., Chattopadhyay, Debasish
Publicat 2011

Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

per Quenelle, Debra C., Prichard, Mark N., Keith, Kathy A., Hruby, Dennis E., Jordan, Robert, Painter, George R., Robertson, Alice, Kern, Earl R.
Publicat 2007

Isolation and characterization of cidofovir resistant vaccinia viruses

per Becker, Marie N, Obraztsova, Maria, Kern, Earl R, Quenelle, Debra C, Keith, Kathy A, Prichard, Mark N, Luo, Ming, Moyer, Richard W
Publicat 2008

SYNTHESIS, METABOLIC STABILITY AND ANTIVIRAL EVALUATION OF VARIOUS ALKOXYALKYL ESTERS OF CIDOFOVIR AND (S)-[3-HYDROXY-2-(PHOSPHONOMETHOXY)PROPYL]ADENINE

per Ruiz, Jacqueline, Beadle, James R., Buller, R. Mark, Schreiwer, Jill, Prichard, Mark N., Keith, Kathy A., Lewis, Kenneth C., Hostetler, Karl Y.
Publicat 2011

Effect of Oral Treatment with Hexadecyloxypropyl-[(S)-9-(3-Hydroxy-2- Phosphonylmethoxypropyl)Adenine] [(S)-HPMPA] or Octadecyloxyethyl-(S)-HPMPA on Cowpox or Vaccinia Virus Infect...

per Quenelle, Debra C., Collins, Deborah J., Herrod, Bridgett P., Keith, Kathy A., Trahan, Julissa, Beadle, James R., Hostetler, Karl Y., Kern, Earl R.
Publicat 2007

Antiviral Evaluation of Octadecyloxyethyl Esters of (S)-3-Hydroxy-2-(phosphonomethoxy)propyl Nucleosides Against Herpesviruses and Orthopoxviruses

per Valiaeva, Nadejda, Prichard, Mark N., Buller, R. Mark, Beadle, James R., Hartline, Caroll B., Keith, Kathy A., Schriewer, Jill, Trahan, Julissa, Hostetler, Karl Y.
Publicat 2009

Antiviral Activities of Novel 5-Phosphono-Pent-2-en-1-yl Nucleosides and Their Alkoxyalkyl Phosphonoesters

per Choo, Hyunah, Beadle, James R., Kern, Earl R., Prichard, Mark N., Keith, Kathy A., Hartline, Caroll B., Trahan, Julissa, Aldern, Kathy A., Korba, Brent E., Hostetler, Karl Y.
Publicat 2007

Selective Phosphorylation of Antiviral Drugs by Vaccinia Virus Thymidine Kinase

per Prichard, Mark N., Keith, Kathy A., Johnson, Mary P., Harden, Emma A., McBrayer, Alexis, Luo, Ming, Qiu, Shihong, Chattopadhyay, Debasish, Fan, Xuesen, Torrence, Paul F., Kern, Earl R.
Publicat 2007

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides

per Williams, John D., Khan, Atiyya R., Harden, Emma A., Hartline, Caroll B., Jefferson, Geraldine M., Keith, Kathy A., Prichard, Mark N., Zemlicka, Jiri, Peet, Norton P., Bowlin, Terry L.
Publicat 2012

New Small Molecule Entry Inhibitors Targeting Hemagglutinin-Mediated Influenza A Virus Fusion

per Basu, Arnab, Antanasijevic, Aleksandar, Wang, Minxiu, Li, Bing, Mills, Debra M., Ames, Jessica A., Nash, Peter J., Williams, John D., Peet, Norton P., Moir, Donald T., Prichard, Mark N., Keith, Kathy A., Barnard, Dale L., Caffrey, Michael, Rong, Lijun, Bowlin, Terry L.
Publicat 2014

N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of Novel Orthopoxvirus Egress Inhibitors

per Bailey, Thomas R., Rippin, Susan R., Opsitnick, Elizabeth, Burns, Christopher J., Pevear, Daniel C., Collett, Marc S., Rhodes, Gerry, Tohan, Sanjeev, Huggins, John W., Baker, Robert O., Kern, Earl R., Keith, Kathy A., Dai, Dongcheng, Yang, Guang, Hruby, Dennis, Jordan, Robert
Publicat 2007