Antiviral Evaluation of Octadecyloxyethyl Esters of (S)-3-Hydroxy-2-(phosphonomethoxy)propyl Nucleosides Against Herpesviruses and Orthopoxviruses

Our previous studies showed that esterification of (S)-3-hydroxy-2-(phosphono-methoxy)propyl]adenine (HPMPA) or 1-(S)-[3-hydroxy-2-(phosphonomethoxy)-propyl]cytosine (HPMPC) with alkoxyalkyl groups such as hexadecyloxypropyl (HDP) or octadecyloxyethyl (ODE) resulted in large increases in antiviral a...

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Detalhes bibliográficos
Main Authors: Valiaeva, Nadejda, Prichard, Mark N., Buller, R. Mark, Beadle, James R., Hartline, Caroll B., Keith, Kathy A., Schriewer, Jill, Trahan, Julissa, Hostetler, Karl Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787864/
https://ncbi.nlm.nih.gov/pubmed/19800369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2009.09.012
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