Inhibition of HIV-1 by Octadecyloxyethyl Esters of (S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl] Nucleosides and Evaluation of Their Mechanism of Action

(S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC [cidofovir]) and (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) are potent inhibitors of a variety of DNA viruses. These drugs possess a 3′-hydroxyl equivalent which could support chain extension from an incorporated drug molec...

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Main Authors: Magee, Wendy C., Valiaeva, Nadejda, Beadle, James R., Richman, Douglas D., Hostetler, Karl Y., Evans, David H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195056/
https://ncbi.nlm.nih.gov/pubmed/21896914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05161-11
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