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Antiproliferative Effects of Octadecyloxyethyl 9-[2-(Phosphonomethoxy)Ethyl]Guanine against Me-180 Human Cervical Cancer Cells in vitro and in vivo

BACKGROUND/AIMS: 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) is one of the most active antiproliferative compounds in a series of acyclic nucleoside phosphonates and is active in intraperitoneal P388 tumors in mice. METHODS: We synthesized octadecyloxyethyl (ODE) and hexadecyloxypropyl esters of PME...

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Autores principales: Valiaeva, Nadejda, Trahan, Julissa, Aldern, Kathy A., Beadle, James R., Hostetler, Karl Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: S. Karger AG 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914419/
https://ncbi.nlm.nih.gov/pubmed/20215748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000292582
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