Identification of Protein-Protein Interaction Inhibitors Targeting Vaccinia Virus Processivity Factor for Development of Antiviral Agents

Poxvirus uracil DNA glycosylase D4 in association with A20 and the catalytic subunit of DNA polymerase forms the processive polymerase complex. The binding of D4 and A20 is essential for processive polymerase activity. Using an AlphaScreen assay, we identified compounds that inhibit protein-protein...

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Detalhes bibliográficos
Main Authors: Schormann, Norbert, Sommers, Charnell Inglis, Prichard, Mark N., Keith, Kathy A., Noah, James W., Nuth, Manunya, Ricciardi, Robert P., Chattopadhyay, Debasish
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195037/
https://ncbi.nlm.nih.gov/pubmed/21844323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00278-11
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