Activity and Mechanism of Action of N-Methanocarbathymidine against Herpesvirus and Orthopoxvirus Infections

N-Methanocarbathymidine [(N)-MCT] is a conformationally locked nucleoside analog that is active against some herpesviruses and orthopoxviruses in vitro. The antiviral activity of this molecule is dependent on the type I thymidine kinase (TK) in herpes simplex virus and also appears to be dependent o...

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Detalhes bibliográficos
Main Authors: Prichard, Mark N., Keith, Kathy A., Quenelle, Debra C., Kern, Earl R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426929/
https://ncbi.nlm.nih.gov/pubmed/16569849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1336-1341.2006
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