Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

Influenza viruses constitute a major health threat and economic burden globally, frequently exacerbated by pre-existing or rapidly emerging resistance to antiviral therapeutics. To address the unmet need of improved influenza therapy, we have created EIDD-2801, an isopropylester prodrug of the ribon...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Toots, Mart, Yoon, Jeong-Joong, Cox, Robert M, Hart, Michael, Sticher, Zachary M, Makhsous, Negar, Plesker, Roland, Barrena, Alec H, Reddy, Prabhakar G., Mitchell, Deborah G, Shean, Ryan C, Bluemling, Gregory R, Kolykhalov, Alexander A, Greninger, Alexander L, Natchus, Michael G, Painter, George R, Plemper, Richard K
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848974/
https://ncbi.nlm.nih.gov/pubmed/31645453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax5866
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