Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

Influenza viruses constitute a major health threat and economic burden globally, frequently exacerbated by pre-existing or rapidly emerging resistance to antiviral therapeutics. To address the unmet need of improved influenza therapy, we have created EIDD-2801, an isopropylester prodrug of the ribon...

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Pubblicato in:Sci Transl Med
Autori principali: Toots, Mart, Yoon, Jeong-Joong, Cox, Robert M, Hart, Michael, Sticher, Zachary M, Makhsous, Negar, Plesker, Roland, Barrena, Alec H, Reddy, Prabhakar G., Mitchell, Deborah G, Shean, Ryan C, Bluemling, Gregory R, Kolykhalov, Alexander A, Greninger, Alexander L, Natchus, Michael G, Painter, George R, Plemper, Richard K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848974/
https://ncbi.nlm.nih.gov/pubmed/31645453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax5866
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