4’-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

The COVID-19 pandemic has underscored the critical need for broad-spectrum therapeutics against respiratory viruses. Respiratory syncytial virus (RSV) is a major threat to pediatric patients and the elderly. We describe 4’-fluorouridine (4’-FlU, EIDD-2749), a ribonucleoside analog that inhibits RSV,...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Sourimant, Julien, Lieber, Carolin M, Aggarwal, Megha, Cox, Robert M, Wolf, Josef D, Yoon, Jeong-Joong, Toots, Mart, Ye, Chengin, Sticher, Zachary, Kolykhalov, Alexander A, Martinez-Sobrido, Luis, Bluemling, Gregory R, Natchus, Michael G, Painter, George R, Plemper, Richard K
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8142655/
https://ncbi.nlm.nih.gov/pubmed/34031658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.05.19.444875
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