Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex

Respiratory syncytial virus (RSV) represents a significant health threat to infants and to elderly or immunocompromised individuals. There are currently no vaccines available to prevent RSV infections, and disease management is largely limited to supportive care, making the identification and develo...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cox, Robert M., Toots, Mart, Yoon, Jeong-Joong, Sourimant, Julien, Ludeke, Barbara, Fearns, Rachel, Bourque, Elyse, Patti, Joseph, Lee, Edward, Vernachio, John, Plemper, Richard K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204889/
https://ncbi.nlm.nih.gov/pubmed/30206124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004862
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