Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex

Respiratory syncytial virus (RSV) represents a significant health threat to infants and to elderly or immunocompromised individuals. There are currently no vaccines available to prevent RSV infections, and disease management is largely limited to supportive care, making the identification and develo...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Cox, Robert M., Toots, Mart, Yoon, Jeong-Joong, Sourimant, Julien, Ludeke, Barbara, Fearns, Rachel, Bourque, Elyse, Patti, Joseph, Lee, Edward, Vernachio, John, Plemper, Richard K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204889/
https://ncbi.nlm.nih.gov/pubmed/30206124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004862
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