Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

Influenza viruses constitute a major health threat and economic burden globally, frequently exacerbated by pre-existing or rapidly emerging resistance to antiviral therapeutics. To address the unmet need of improved influenza therapy, we have created EIDD-2801, an isopropylester prodrug of the ribon...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Toots, Mart, Yoon, Jeong-Joong, Cox, Robert M, Hart, Michael, Sticher, Zachary M, Makhsous, Negar, Plesker, Roland, Barrena, Alec H, Reddy, Prabhakar G., Mitchell, Deborah G, Shean, Ryan C, Bluemling, Gregory R, Kolykhalov, Alexander A, Greninger, Alexander L, Natchus, Michael G, Painter, George R, Plemper, Richard K
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848974/
https://ncbi.nlm.nih.gov/pubmed/31645453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax5866
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