Efficacy of CMX001 Against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

CMX001, an orally active lipid conjugate of cidofovir (CDV), is 50 times more active in vitro against herpes simplex virus (HSV) replication than acyclovir (ACV) or CDV. These studies compared the efficacy of CMX001 to ACV in BALB/c mice inoculated intranasally with HSV types 1 or 2. CMX001 was effe...

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Huvudupphovsmän: Quenelle, Debra C., Lampert, Bernhardt, Collins, Deborah J., Rice, Terri L., Painter, George R., Kern, Earl R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957530/
https://ncbi.nlm.nih.gov/pubmed/20923374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/656717
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